Rybelsus (Semaglutide)
5.0

Rybelsus (Semaglutide)

Rybelsus is a revolutionary new oral Type 2 diabetes medication containing the active ingredient semaglutide. This innovative product from Novo Nordisk was approved by Health Canada in 2019. Unlike injectable analogues, Rybelsus comes in tablet form and does not require daily injections. The convenience of pill administration promotes better patient adherence.

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Rybelsus® tablets (semaglutide) is a prescription medicine used in adults with type 2 diabetes mellitus to decrease blood sugar levels.

Home » Diabetes » Rybelsus (Semaglutide)
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Reviewed By Olivia Irving, PhD

Dr. Olivia Irving is a licensed pharmacist with over 15 years of experience in both hospital and retail pharmacy settings. Her professional interests include pharmacotherapy, preventative medicine, and patient education

Last Updated: December 21, 2024

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Rybelsus (semaglutide) is an innovative drug that is widely used for the treatment of type 2 diabetes and weight management. The active substance in Ribelsus, semaglutide, belongs to the GLP-1 class of medications and works by lowering blood glucose levels and increasing the body’s response to insulin to effectively control diabetes. This drug has proven to not only help lower blood sugar levels, but also reduce the risk of heart attack, stroke, and death in patients with type 2 diabetes.

Rybelsus is usually prescribed along with other treatments, such as exercise and diet changes, to help patients lose weight and prevent serious complications caused by diabetes. Ribelsus is available in the form of tablets for oral administration, which makes it convenient to use. Other brand names of semaglutide include Wegovy and Ozempic, which are given as a subcutaneous injection (injection under the skin).

Rybelsus has also been shown to be effective in helping patients with diabetes control their blood sugar and achieve weight loss. It works by helping to release your body’s natural insulin and improves overall pancreatic function. Rybelsus is used in combination with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

It is important to note that Rybelsus is not intended to treat type 1 diabetes and should not be taken if you are allergic to semaglutide. Therefore, before starting treatment, it is important to consult a specialist. Select your desired dosage below to view Rybelsus prices and place your order. Save up to 80% on the price of Rybelsus when you buy Rybelsus online from a trusted online pharmacy.

Rybelsus for Weight Loss

While Rybelsus is primarily used to manage type 2 diabetes, it has also shown potential for weight loss in some individuals. It’s important to note that Rybelsus is not specifically approved by the FDA as a weight loss medication. Clinical studies have demonstrated that individuals taking Rybelsus alongside lifestyle modifications experienced weight loss over a period of time. In one study, participants with an average weight of 196 pounds who took the lowest dose of Rybelsus lost approximately 5 pounds over 6 months. However, it’s essential to recognize that weight loss outcomes can vary among individuals, and some may even experience weight gain while taking Rybelsus.

The weight loss observed with Rybelsus can be attributed to various factors. Firstly, Rybelsus works by helping to control blood sugar levels, which may indirectly contribute to weight loss by improving metabolic function. Secondly, individuals are typically advised to incorporate healthy eating habits and regular exercise while taking Rybelsus to manage their diabetes, both of which can promote weight loss. It’s worth noting that the weight loss experienced may also be influenced by other medications used in conjunction with Rybelsus, as well as individual metabolic differences.

How to Take?

Ribelsus is intended for oral administration once a day, in the morning on an empty stomach, at least 30 minutes before meals. It is recommended to take the tablet with water, swallowing it whole, without chewing. It is important to follow the dosage regimen prescribed by your doctor to maintain stable blood levels of semaglutide.

Therapy should be started with a dose of 3 mg once a day. After 1 month, if well tolerated, the doctor may increase the dosage to 7 mg once a day. After another month, a further increase to 14 mg once a day is possible, which is the maximum daily dose.

If the next dose of Ribelsus is missed, it can be taken during the same day. Do not take 2 doses at the same time if you miss a dose. After you resume taking Ribelsus, you must strictly follow the usual dosage regimen recommended by your doctor.

Benefits of Ribelsus therapy

Several clinical studies have highlighted the advantages of utilizing Rybelsus in individuals with type 2 diabetes:

  • A significant reduction in glycated hemoglobin levels (by 1-1.5%), indicating successful long-term glycemic control.
  • Consistent maintenance of normal fasting glucose levels and postprandial glucose levels.
  • Moderate weight loss (averaging 2-4 kg) attributed to appetite suppression.
  • Ease of administration in tablet form compared to injections of other incretin drugs.
  • Ability to be taken once daily without compromising efficacy.
  • Favorable safety profile and tolerability.

Rybelsus demonstrates notable efficacy in reducing hyperglycemia while posing a relatively low risk of adverse effects.

Rybelsus Side Effects

The most common Rybelsus side effects are nausea, vomiting, diarrhea, and decreased appetite. Serious complications like pancreatitis, vision changes or kidney failure require prompt medical attention.

Who is Rybelsus Suitable For?

Rybelsus is recommended for adult patients with Type 2 diabetes who require drug therapy in addition to lifestyle changes. It is especially beneficial in cases of inadequate disease control with metformin and other oral antidiabetic drugs.

Rybelsus may be a good alternative to injectable incretin preparations like Victoza or Trulicity for patients who prefer oral medication. However, a consultation with an endocrinologist is important before starting treatment.

Rybelsus Contraindications

Rybelsus should not be taken in cases of Type 1 diabetes, diabetic ketoacidosis, severe renal or hepatic impairment. It is not approved for use in pediatric patients under 18 years of age.

Rybelsus is also contraindicated in patients with a personal or family history of medullary thyroid carcinoma and Multiple Endocrine Neoplasia syndrome type 2.

The doctor should carefully review the patient’s medical history prior to prescribing Rybelsus in order to rule out potential contraindications and minimize complication risks.

Rybelsus (Semaglutide)
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